The purpose of the Guide is to provide practical and actionable recommendations for effective teleworking that are applicable to a broad range of actors; to support policymakers in updating existing policies; and to provide a flexible framework through which both private enterprises and public sector organizations can develop or update their own teleworking policies and practices. The Guide also includes a number of case examples regarding how employers and policymakers have been handling teleworking during the COVID-19 pandemic and addresses the lessons learned from the recent months that are relevant for the future of teleworking arrangements beyond the pandemic; and a list of available tools and resources. 1. Introduction -- 2. Entering a new era of teleworking -- 3. Ensuring the well-being of workers and continued productivity while teleworking -- 4. The gender dimension of teleworking during the COVID-19 pandemic -- 5. Trust and organizational culture -- 6. Policy responses for supporting employers and workers in introducing and sustaining effective teleworking -- 7. The future of teleworking post-COVID-19 -- Annex 1. Tools and resources developed to respond to the COVID-19 pandemic -- Annex 2. The most frequently used forms of communication during the COVID-19 pandemic -- Annex 3. Checklist -- Annex 4. Comparative table of 3 national teleworking laws Italy, El Salvador and Chile) -- Annex 5. Case Examples.