The Manual builds on and replaces the generic United Nations National Quality Assurance Framework template and guidelines (UN NQAF template and guidelines) adopted in 2012. Specifically, the United Nations National Quality Assurance Framework (UN NQAF) contained in Chapter 3 and Annex A of the Manual fully corresponds to and replaces the UN NQAF template and guidelines of 2012. In Chapter 2 the Manual provides recommendations, Chapters 4 to 8 provide implementation guidance and Chapter 9 provides additional information and references regarding quality assurance in the global context. 1. Content and use of the Manual -- 2. Recommendations on quality assurance for official statistics -- 3. United Nations National Quality Assurance Framework: principles and requirements -- 4. Assessment tools and risk management -- 5. Development and implementation of a national quality assurance framework -- 6. Implementation of quality assurance within the national statistical system -- 7. Quality assurance for statistics compiled from different data sources -- 8. Quality assurance of data and statistics on Sustainable Development Goal indicators -- 9. Quality assurance in the global statistical system -- Annex Detailed list of elements to be assured.