The Technology and Innovation Report 2018 discusses the role of frontier technologies in sustainable development. It outlines the main features and the manifold ways in which they can accelerate development. The report also identifies some potential risks, describes the capability, gender, and infrastructural gaps that need to be address, and discusses policy options, including some innovative policy approaches, that countries can consider to maximize the development benefits and minimize the risks of frontier technologies. Overview Chapter 1. Frontier technologies and sustainable development -- Chapter 2. Benefitting from frontier technologies: gaps and capabilities -- Chapter 3. Foundations of STI policy for sustainable and inclusive development -- Chapter 4. Frontier technologies, emerging approaches and opportunities.